To set up your HP DJ 2622 Printer Setup, first unbox it and remove all packaging materials. Connect the power cord to the printer and a wall outlet, then install the ink cartridges and load paper into the tray. Next, download the printer software from the HP website and follow the on-screen instructions to install it on your computer. Connect the printer to your computer using a USB cable, and use the software to set up the wireless connection or use the control panel on the printer. Finally, perform a test print to ensure the printer is working properly.